Candida albicans Germ Tube Antibody (CAGTA) Background
Candida albicans is an opportunistic fungus and one of the leading causes of invasive candidiasis (IC), a serious healthcare-associated infection associated with high morbidity and mortality, particularly in critically ill, immunocompromised, transplant, and oncology patients, as well as those admitted to intensive care units (ICUs).
During tissue invasion, C. albicans undergoes a morphological transition from the yeast form to germ tubes and hyphal forms. This transformation is closely linked to fungal virulence and to the expression of specific cell wall antigens that are generally not expressed during simple colonization.
The host immune response against these germ tube-associated antigens induces the production of specific IgG antibodies known as Candida albicans Germ Tube Antibodies (CAGTA). These antibodies serve as immunological markers of invasive infection and may contribute to the diagnosis of invasive candidiasis, particularly when used in combination with other microbiological and clinical findings.
Product features
Indirect chemiluminescent immunoassay to test antibodies against antigens located on the cell wall surface of the micelium of Candida albicans (CAGTA Candida albicans germ tube antibody) in human serum or plasma.
- Discriminates between infection and colonization
- High Negative Predictive Value (NPV)
- Highly convenient solution to urgent samples
- Monotest format with ready-to-use reagents
- Simple and automated protocol with fast results
- Allows pipetting from primary sample tube, no further manipulation is needed
PRODUCTS
INVASIVE CANDIDIASIS (CAGTA) VIRCLIA® IgG MONOTEST
Analytes: Candida albicans
USED ON
VIRCLIA® LOTUS
A compact automated CLIA platform for VirClia® infectious disease testing, combining ready-to-use single-test flexibility with continuous random access efficiency.
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